Cutting Carbs, Cutting Protein
When I started this experiment, I was 10 pounds above my goal weight of 140 pounds, having already lost 40 pounds over three years with 20:4 intermittent fasting. Today I'm just 3 pounds away.
What finally broke my plateau at 150 pounds was adding two ketogenic days each week. In fact, my weight had begun creeping upward, and those low-carb days got things moving again. Once I reach 140 pounds, I expect I'll only need one ketogenic day each week to maintain my weight.
That doesn't mean I think a ketogenic diet is the healthiest way to eat long term. With its high fat intake and very low fiber, it simply doesn't compare nutritionally with a GBOMBS-style diet. If you compare a typical ketogenic day with a typical GBOMBS day in Cronometer, the difference in micronutrients and fiber is striking.
To me, keto is a metabolic tool rather than a lifestyle.
I've begun thinking about protein in much the same way. If I'm preparing for a longer fast to promote autophagy, it seems reasonable that reducing protein for a couple of days beforehand might help my body make that transition more readily by lowering amino acid intake and mTOR activity.
I'm especially interested in autophagy because of its potential role in healthy aging. At my age, anything that helps the body recycle damaged cellular components is intriguing, and I'm particularly interested in the possibility that it could contribute to cancer prevention or improve cellular resilience—although much remains to be learned about how these effects translate to humans.
My next experiment will be a five-day fasting-mimicking diet following the general guidelines described in The Longevity Diet. During the two days leading up to it, I plan to reduce my protein intake to an absolute minimum and see how the experience compares with beginning the fast without that preparation.